I have always found it cool when eyes light up like that! And with that effect on Loki, DAYUM!! That's SWEET! LUV IT!
I am completely in love with this fanart, mainly because is something I have imagine to happen if Loki would ever stay in possession of the sceptre for too long - the infinity gem taking control over him, burning out everything, before only what is left is the purpose, changing his eyes permanently blue. Maybe I'm reading to much to this, if so forgive me.
This fanart was the result of reading way too much fanfiction, I had made an entire backstory in my head that I was hoping to visualise. So it's awesome that you read into this so much because that was exactly what I intended.
Amazing as always